Autophage is Expanding Its Patented Set of Novel Autophagy Stimulating Therapeutics as Treatments for Diseases such as ALS, Alzheimer’s, Parkinson’s, Multiple Sclerosis and Many More…
Neuroguard
Changing the Landscape for the Treatment of Neurodegenerative Diseases
Autophagy “composts” or “recycles” garbage from the brain and nerve cells of the body.
Misfolded proteins in typical neurodegenerative diseases
- Alzheimer’s disease (AD)
Hyper-phosphorylated tau protein
Misfolded amyloid β (Aβ) protein
- Amyotrophic lateral sclerosis (ALS)
Familial ALS: Mutations in C9orf72, SOD1, TDP-43 or FUS
Sporadic ALS: Recently reported association with TDP-43 and FUS
- Parkinson’s disease (PD)
Aggregation of α-synuclein
Mutations in parkin, DJ-1 or PINK1
Neuroprotective effects of LKE in different disease models
Disease | Model | Activity |
ALS | SOD1ᴳ⁹³ᴬ mice | Improves motor function, slows disease progression, increases overall survival |
AD | 3xTg-AD mice | Decreases microglial activation, reduces amyloid burden and phosphorylated-tau accumulation inside neurons, slows cognitive decline |
AD | Okadaic acid treated zebra fish | Protects against cognitive impairments, reduces brain cell apoptosis, increases BDNF, pAkt and pCREB |
Spinal Cord Injury | female mice | Promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth |
Multiple Sclerosis | EAE mice | Reduces clinical signs of MS, decreases IFNγ production in splenic T cells |
Multiple Sclerosis | Cuprizone mice | Accelerates remyelination following chemically induced, non-inflammatory demyelination by cuprizone (CPZ) |
Second generation LK analogues structure design
Our patented multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters
- Introduction of functional group at the C-2 position
- Replacement of the carboxylic acid group with a phosphonic acid group at the C-3 position
