Changing the Landscape for the Treatment of Neurodegenerative Diseases

Autophage is Expanding Its Patented Set of Novel Autophagy Stimulating Therapeutics as Treatments for Diseases such as ALS, Alzheimer’s, Parkinson’s, Multiple Sclerosis and Many More…

Autophagy “composts” or “recycles” garbage from the brain and nerve cells of the body.

Misfolded proteins in typical neurodegenerative diseases

  • Alzheimer’s disease (AD)
    Hyper-phosphorylated tau protein
    Misfolded amyloid β (Aβ) protein
  • Amyotrophic lateral sclerosis (ALS)
    Familial ALS: Mutations in C9orf72, SOD1, TDP-43 or FUS
    Sporadic ALS: Recently reported association with TDP-43 and FUS
  • Parkinson’s disease (PD)
    Aggregation of α-synuclein
    Mutations in parkin, DJ-1 or PINK1

Neuroprotective effects of LKE in different disease models





SOD1ᴳ⁹³ᴬ mice

Improves motor function, slows disease progression, increases overall survival


3xTg-AD mice

Decreases microglial activation, reduces amyloid burden and phosphorylated-tau accumulation inside neurons, slows cognitive decline


Okadaic acid treated zebra fish

Protects against cognitive impairments, reduces brain cell apoptosis, increases BDNF, pAkt and pCREB

Spinal Cord Injury

female mice

Promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth

Multiple Sclerosis

EAE mice

Reduces clinical signs of MS, decreases IFNγ production in splenic T cells

Multiple Sclerosis

Cuprizone mice

Accelerates remyelination following chemically induced, non-inflammatory demyelination by cuprizone (CPZ)

Second generation LK analogues structure design

Our patented multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters

  • Introduction of functional group at the C-2 position
  • Replacement of the carboxylic acid group with a phosphonic acid group at the C-3 position
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